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Clinical Infectious Diseases ; 71(16):2272-2275, 2020.
Article in English | CAB Abstracts | ID: covidwho-1165366

ABSTRACT

Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3<sup>+</sup> T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.

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